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Past Research

Latino End-of-Life Care: Patient, Provider, & Institutional Effects

Principal Investigators

Holly Prigerson, Ph.D., Paul Maciejewski, Ph.D.

The primary aims of the study is to obtain multi-level data and use hierarchical linear modeling (HLM) to estimate patient, provider, and institutional effects on Latino-White disparities in EoL care and treatment goal attainment.  

Major Publications

25145489

Sponsored by

National Institute of Health, National Cancer Institute

Psychiatric Disorder in Dying Patients & Their Survivors R01MH063892

Principal Investigators

Holly Prigerson, Ph.D.

This study aims to determine 1) the prevalence of psychiatric disorders and their treatment among terminally ill cancer patients and their primary caregivers and 2) the influence of the patients’ mental health on their degree of comfort at the time of death (eg, lack of pain, physical, emotional, social, existential distress). 

Sponsored by

National Institute of Mental Health

Traumatic Grief in Later-Life: Criteria, Risks, Outcomes

Principal Investigators

Holly Prigerson, Ph.D.

The primary aim of this study is to test the performance of the consensus criteria for traumatic grief (TG) and to define parameters that would help formulate a set of standardized criteria for TG. 

Sponsored by

National Institute of Mental Health

Psychosocial Factors in Depression Among Bereaved Elders K21MH001100

Principal Investigators

Holly Prigerson, Ph.D.

The overarching aim of this study is to identify the most promising targets for interventions designed to enable Latinos to receive: a) high quality EoL care, and b) care consistent with their values and preferences (“treatment goal attainment”). This study will obtain multi-level data and use hierarchical linear modeling (HLM) to estimate patient, provider and institutional effects on Latino-White disparities in EoL care and treatment goal attainment. 

Sponsored by

National Cancer Institute

Dynamic fMRI to Measure Neuronal Activity K25NS044316

Principal Investigators

Paul Maciejewski, Ph.D.

This study seeks to 1) develop a 13C MRS method for measuring dynamic changes in the cerebral metabolic rate of oxygen consumption, 2) obtain dynamic, multi-modal measurements of functional activation in a rat model, and 3) develop a neurovascular model of blood oxygenation level dependent (BOLD) signal and functional activation. 

Sponsored by

National Institute of Neurological Disorders and Stroke

U54CA156732

Principal Investigators

Holly Prigerson, Ph.D.

This research initiative developed the comprehensive partnership between the University of Massachusetts Boston (UMB) and the Dana-Farber/Harvard Cancer Center (DFHCC) by addressing health disparities in minority populations, improving research in basic, clinical, and population science, and providing training, research, and outreach opportunities for minority students, nurses, and scientists. 

Sponsored by

National Institute of Health, National Cancer Institute

U54CA156732

Principal Investigators

Holly Prigerson, Ph.D., Paul Maciejewski, Ph.D.

The primary aims of the study is to obtain multi-level data and use hierarchical linear modeling (HLM) to estimate patient, provider, and institutional effects on Latino-White disparities in EoL care and treatment goal attainment.  

Major Publications

25145489

Sponsored by

National Institute of Health, National Cancer Institute

Young Adult Coping with Cancer Study

Principal Investigators

Holly Prigerson, Ph.D.

This study examined the prevalence of psychological distress and psychiatric illness in young adults with advanced cancer and identified risk and protective factors (e.g., social support, spirituality, coping styles) affecting the likelihood of psychosocial distress in young adults with cancer.  It also explored how medical-pharmacological factors (e.g., cancer treatment and adherence, clinical relationships and communications, substance abuse) and psychosocial factors (e.g., spirituality, mental health interventions) influence the health and broader social functioning of YAs with cancer.  

Major Publications 

24888503235301052279022322285777

R01CA106370

Principal Investigators

Holly Prigerson, Ph.D., Paul Maciejewski, Ph.D.

The Coping with Cancer (CwC) study is a national, multicenter, prospective cohort study of advanced cancer patients and their family caregivers who survive them. The Coping with Cancer study has generated a program of research that has included examination of: ethnic disparities in and mediators of end-of-life care; the effects of prognostic discussions on patients’ emotional and cognitive acceptance of their terminal illness, healthcare and costs of healthcare received in the last week of life; studies of factors predicting patient end-of-life treatment preferences, quality of death, and surviving caregiver bereavement adjustment. The study has completed data collection and has resulted in over 50 publications in peer reviewed medical journals.

Major Publications

25145489250521382488850324321508243016442409989424053593237624672364965623536809

Sponsored by

National Cancer Institute and National Institute of Mental Health

Contact Information

Center for Research on End-of-Life Care Weill Cornell Medical College 525 E 68th St, Box 39, 1414 Baker Pavilion New York, NY 10065 Phone: (212) 746-4409